Warren R. Zipfel
Associate Professor of Biomedical Engineering

Warren R. Zipfel


(607) 255-0663


Dept. of Biomedical Engineering
B41 Weill Hall
Cornell University
Ithaca, NY 14853-2501


Web Sites

Department Profile
Background Ph.D. 1993, Cornell University, Biophysics
B.S. 1987, Cornell University, Biochemistry

Research Description

My engineering research focus is on the development and application of optical microscopy for biomedical research and for clinical imaging applications, with a primary effort on nonlinear microscopy. I serve as Director of the Developmental Resource for Biophysical Imaging and Optoelectronics (DRBIO), the NIH-funded center that originally developed multiphoton imaging in 1990. My lab is involved in numerous optical instrumentation development projects and the creation of new bioanalytical methods for studies in cell signaling and regulation. The biological research focus in my lab has been in the areas of optical detection of cancer, and collaborative studies in cancer biology, transcription and nuclear regulation and in neurobiology.


Degala, S; Zipfel, Warren R.; Bonassar, Lawrence. "Chondrocyte calcium signaling response to fluid flow is regulated by matrix adhesion in 3D alginate scaffolds." Arch Biochem Biophys 505. 1 (2011) 112-117

Degala, S; Williams, Rebecca M; Zipfel, Warren R.; Bonassar, Lawrence. "Calcium signaling in response to fluid flow by chondrocytes in 3D alginate culture." Osteoarthritis Cart (2011)

Tewari, A K; Mukherjee, S; Herman, M; Yadav, R; Mudalair, K; Sterling, J; Grover, S; Sheychuk, M M; Rubin, M A; Maxfield, F R; Zipfel, Warren R.; Webb, W W. "Multiphoton microscopy for structure identification in human prostate And periprostatic tissue: implications in prostate cancer surgery." British Journal of Urology International (2011)

Jain, M; Robinson, B D; Scherr, D S; Joshua Sterling, J; Ming-Ming Lee, M; Wysock, J; Rubin, M A; Maxfield, F R; Zipfel, Warren R.; Webb, W W; Mukherjee, S. "Multiphoton microscopy in the evaluation of human bladder biopsies." Modern Pathology (2011

Bowles, R D; Williams, Rebecca M; Zipfel, Warren R.; Bonassar, Lawrence. "Self-assembly of aligned tissue-engineered annulus fibrosus and intervertebral disc composite via collagen gel contraction." Tissue Eng Part A 16. 4 (2010) 1339-1348