Holger Sondermann

Holger Sondermann


607-253-3659 (fax)


Department of Molecular Medicine
C4-161, Veterinary Medicine Center
College of Veterinary Medicine
Cornell University
Ithaca, NY 14853-2703


Web Sites

Lab Web Site


  • PEW Scholar in the Biomedical Sciences
  • University of California, Berkeley, USA
    October 2001 - August 2005: Postdoctoral work, supervisor: Prof. Dr. J. Kuriyan
  • The Rockefeller University, New York, USA
    July 2001 - October 2001: Postdoctoral work, supervisor: Prof. Dr. J. Kuriyan
  • Max-Planck-Institute of Biochemistry, Martinsried, Germany
    November 1997 - June 2001: PhD dissertation, supervisor: Prof. Dr. F. U. Hartl (summa cum laude)
  • University of Cologne, Germany
    October 1992 - October 1997: Diploma in Biology
  • Kaiserin-Theophanu-Gymnasium, Cologne, Germany
    August 1983 - May 1992: Abitur

Research Description

Cells respond to a large variety of signals using only a limited set of signaling modules which are organized in complex networks. The activity of these signaling switches is spatially and temporally regulated, and this regulation governs normal development and cellular homeostasis. Consequently, uncontrolled activation is a hallmark of many diseases such as cancer. It is therefore not surprising that the cell has intricate regulatory mechanisms in place to control signal transduction.

Our lab is interested in deciphering the basic regulatory principles in signal transduction networks on a molecular level using a combination of X-ray crystallography, biophysical and cellular approaches. We focus on two main areas of research: Bacterial signaling controlling biofilm formation and pathogenicity, and endocytosis in eukaryotes.


  • Byrnes, L.J., and Sondermann, H. (2011). Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A. Proc Natl Acad Sci USA 108(6): 2216-2221.
  • Navarro, M.V.A.S.*, Newell, P.D.*, Krasteva, P.V.*, Chatterjee, D.*, Madden, D.R., O’Toole, G.A., and Sondermann, H. (2011). Structural basis for c-di-GMP-mediated inside-out signaling controlling periplasmic proteolysis. PLoS Biology 9(2): e1000588.
    (*These authors contributed equally to this work.)
  • Newell, P.D., Boyd, C., Sondermann, H., and O’Toole, G.A. (2011). A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage. PLoS Biology 9(2): e1000587.
  • De, N., Navarro, M.V.A.S., Wang, Q., Krasteva, P.V., and Sondermann, H. (2010). Biophysical assays for protein interactions in the Wsp sensory system and biofilm formation. Methods in Enzymology 471: 161-84.
  • Krasteva, P.V., Fong, J.C.N., Shikuma, N.J., Beyhan, S., Navarro, M.V.A.S., Yildiz, F.H.*, and Sondermann, H.* (2010). Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science 327: 866-868.
    (*Co-corresponding authors.)
  • De, N., Navarro, M.V.A.S., Raghavan, R.V., and Sondermann, H. (2009). Determinants for the activation and autoinhibition of the diguanylate cyclase response regulator WspR. J Mol Biol 393(3): 619-633.
  • Navarro, M.V.A.S.*, De, N.*, Bae, N., Wang, Q., and Sondermann, H. (2009). Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX. Structure 17(8): 1104-1116.
    (*These authors contributed equally to this work.)
  • Wang, Q., Navarro, M.V.A.S., Peng, G., Molinelli, E., Goh, S.L., Judson, B.L., Rajashankar, K.R., and Sondermann, H. (2009). Regulated formation of membrane vesicles and tubules with high and low curvature by Pacsin. Proc Natl Acad Sci USA 106(31): 12700-12705.
  • Wang, Q., Shui, B., Kotlikoff, M.I., and Sondermann, H. (2008). Structural basis for calcium sensing by GCaMP2. Structure 16(12): 1817-1827.
  • Wang, Q., Kaan, H.Y.K., Hooda, R.N., Goh, S.L., and Sondermann, H. (2008). Structure and plasticity of Endophilin and Sorting Nexin 9. Structure 16(10): 1574-1587.
  • De, N., Pirruccello, M., Krasteva, P.V., Bae, N., Raghavan, R.V., and Sondermann, H. (2008). Phosphorylation-independent regulation of the diguanylate cyclase WspR. PLoS Biology, 6(3): e67.

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