Background |
PhD, University of Oklahoma, 1976
BS, Oklahoma State University, 1972
Leukemia Society of America Special Fellow and Scholar Development Award
Office of Naval Research Young Investigator |
Research Description |
We use X-ray crystallography to study the three-dimensional structures of proteins. The structural information is used for drug design, protein engineering, to understand catalytic mechanisms, and to explore protein evolution. Our group is also involved in the development of tools and techniques associated with synchrotron radiation, especially multiple wavelength anomalous diffraction (MAD). Our main projects include studies of enzymes involved in purine nucleotide metabolism and pyrimidine nucleotide metabolism, studies of enzymes involved in co-factor biosynthesis, especially thiamin biosynthesis, and enzymes involved in polyamine biosynthesis. more |
Publications |
Zhang Y, Kang SA, Mukherjee T, Bale S, Crane BR, Begley TP and Ealick SE. Crystal Structure and Mechanism of Tryptophan 2,3-Dioxygenase, a Heme Enzyme Involved in Tryptophan Catabolism and in Quinolinate Biosynthesis. Biochemistry 2007, 46, 145-155.
Morar M, Anand R, Hoskins AA, Stubbe J and Ealick SE. Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP-binding Protein Superfamily. Biochemistry 2006, 45, 14880-14895.
Zein F, Zhang Y, Kang Y-N, Burns K, Begley TP, and Ealick SE. Structural Insights into the Mechanism of the PLP Synthase Holoenzyme from Thermotoga maritima. Biochemistry 2006, 46, 14609-14620.
Jurgenson CT, Chatterjee A, Begley TP and Ealick SE. Structural Insights into the Function of the Thiamin Biosynthetic Enzyme Thi4 from Saccharomyces cerevisiae. Biochemistry 2006, 45, 11061-11070.
Zhang Y, Porcelli M, Cacciapuoti G, and Ealick SE. The Crystal Structure of 5'-Deoxy-5'-Methylthioadenosine Phosphorylase II from Sulfolobus Solfataricus, a Thermophilic Enzyme Stabilized by Intramolecular Disulfide Bonds. J. Mol. Biol. 2006, 357, 252-262. |
