Iwijn De Vlaminck
Robert N. Noyce Assistant Professor in Life Science and Technology

Iwijn De Vlaminck

Phone

650-798-4570

Address

Dept. of Biomedical Engineering
Cornell University
G11 Physical Sciences Building
Ithaca, NY  14853

Email

Web Sites

Lab Website

Department Profile

Background

Iwijn De Vlaminck received a B.S. degree in 2000 and a Master’s degree in 2003 in Electronic Engineering from KULeuven, and a Ph.D. in Science and Engineering in 2008 from KULeuven.  He became an Assistant Professor in the Department of Biomedical Engineering at Cornell University in January 2015.

Research Description

Dr. De Vlaminck's research brings approaches from biophysics to genomics. The lab pursues novel measurement principles in cell-free DNA diagnostics and single cell genomics.

Cell-free DNA. When cells turn over in body tissue, their genomes persist for some time in circulation in the form of cell-free DNA. Cell-free DNA is abundantly present in plasma and provides an information-rich window into human physiology, with rapidly expanding applications in cancer diagnosis and treatment monitoring, prenatal diagnosis, and monitoring of rejection in transplantation. The lab develops assays to interrogate cell-free DNA via sequencing, with an eye on improved accuracy, lower cost and blood volume requirements, and new applications in clinical diagnostics.

Single-cell genomics. Advances in DNA sequencing and microfluidics now make it possible to perform sequence analyses of the genomes and the gene expression programs of single cells. The lab has an interest in the development and application of sensitive single-cell genome sequencing principles, in particular combinations of single cell genome sequencing with microscopy techniques. Applications of single cell sequencing are found in human biology and microbiology.

Publications

Eric D. Becraft, Jeremy A. Dodsworth, Senthil K. Murugapiran, Ingemar Ohlsson, Brandon R. Briggs, Jad Kanbar, Iwijn De Vlaminck, Steven R. Quake, Hailiang Dong, Brian P. Hedlund and Wesley Swingley, Metagenomic analyses of candidate phylum EM19 (Calescamantes) populations in geothermal springs using a novel read-first binning method, submitted (2015).

Iwijn De Vlaminck, Lance Martin, Mickey Kertesz, Kapil Patel, Mark Kowarsky, Calvin Strehl, Garrett S. Cohen, Helen Luikart, Norma F. Neff, Jennifer Okamoto, Mark N. Niccols, David N. Cornfield, David Weill, Hannah A. Valantine, Kiran K. Khush and Stephen R. Quake, Simultaneous non-invasive monitoring of infection and rejection after lung transplantation, submitted (2015).

Christopher Vollmers, Iwijn De Vlaminck, Hannah A.Valantine, Lolita Penland, Helen Luikart, Calvin Strehl, Garrett Cohen, Kiran K. Khush, Stephen R. Quake, Pharmacologically induced immunosuppression can be monitored by immune repertoire sequencing, submitted (2015).

Qiuyuan Huang, Brandon R. Briggs, Hailiang Dong, Hongchen  Jiang,  Geng  Wu,  Christian  Edwardson, Iwijn De Vlaminck, and Stephen Quake, Taxonomic and functional diversity provides insight into microbial pathways and stress responses in the saline Qinghai Lake, China, Plos One, 9, e111681 (2014).

Charles de Bourcy, Iwijn De Vlaminck, Jad kanbar, Jianbin Wang, Charles Gawad, Stephen R. Quake, Quantitative comparison of single-cell whole genome amplification methods, Plos One, 9, e105585 (2014).

Daniel Burnham, Iwijn De Vlaminck, Thomas Henighan and Cees Dekker, Non-normal Brownian fluctuations in magnetic tweezers and consequences for single molecular experiments, Plos One, 9, e108271 (2014).

Iwijn De Vlaminck, Hannah A. Valantine, Thomas M. Snyder, Calvin Strehl, Garrett Cohen, Helen Luikart, Norma F. Neff, Jennifer Okamoto, Daniel Bernstein, Dana Weisshaar, Stephen R. Quake, and Kiran K. Khush, Quantification of circulating donor-specific cell-free DNA for detection of heart transplant injury, Science Translational Medicine, 6, 241ra77 (2014).

Iwijn De Vlaminck, Kiran K. Khush, Calvin Strehl, Bitika Kohli, Helen Luikart, Norma F. Neff, Jennifer Okamoto, Thomas M. Snyder, David N. Cornfield, Mark R. Nicolls, David Weill, Daniel Bernstein, Hannah A. Valantine, and Stephen R. Quake, Temporal response of the human virome in response to immune modulation and antiviral therapy, Cell, 155, 1178 (2013).

Marijn van Loenhout, Iwijn De Vlaminck, Benedetta Flebus, Ludovit Zweifel, Johan den Blanken, Koen Hooning, Jacob Kerssemakers, Cees Dekker, Scanning a DNA molecule for bound proteins using hybrid magnetic and optical tweezers, Plos One, 8, e65329, (2013).

Marijn van Loenhout, Jacob Kerssemakers, Iwijn De Vlaminck, and Cees Dekker, Non-bias-limited tracking of spherical particles, enabling nanometer resolution at low magnification, Biophysical Journal, 102, 2362-2371 (2012).

Iwijn De Vlaminck, Thomas Henighan, Marijn T.J. van Loenhout, Daniel Burnham, and Cees Dekker, Magnetic forces and DNA mechanics in multiplexed magnetic tweezers, Plos One, 7, e41432 (2012).

Iwijn De Vlaminck, Marijn van Loenhout, Ludovit Zweifel, Johan den Blanken, Susanne Hage, Jacob Kerssemakers, and Cees Dekker, Mechanism of homology recognition in DNA recombination from dual molecule experiments, Molecular Cell, 46, 616 (2012).

Iwijn De Vlaminck and Cees Dekker, Recent advances in magnetic tweezers, Annual Reviews of Biophysics, 41, 453-472(2012).

Iwijn De Vlaminck, Thomas Henighan, Marijn T.J. van Loenhout, Indriati Pfeiffer, Julius Huijts, Jacob W. J. Kerssemakers, Allard J. Katan, Anja van Langen-Suurling, Emile van der Drift, Claire Wyman, and Cees Dekker, Highly parallel magnetic tweezers by targeted DNA tethering, Nano Letters, 11, 5489 (2011).

Iwijn De Vlaminck, Iztok Vidic, Marijn van Loenhout, Joyce Lebbink, Roland Kanaar, and Cees Dekker, Torsional regulation of hRPA-induced unwinding of double stranded DNA, Nucleic Acids Research, 38,4133 (2010).

Chang Chen, James Andell Hutchison, Pol Van Dorpe, Ronald Kox, Iwijn De Vlaminck, Hiroshi Ujii, Johan Hofkens, Liesbet Lagae, Guido Maes, and Gustaaf Borghs, Focusing plasmons in nanoslits for surface-enhanced raman scattering, Small, 24, 2876 (2009).

Joris Roels, Iwijn De Vlaminck, Liesbet Lagae, Bjorn Maes, Dries Van Thourhout and Roel Baets, Tunable optical forces between nanophotonic waveguides, Nature Nanotechnology, 4, 510 (2009).

Chengjun Huang, Kristien Bonroy, Gunter Reekmans, Wim Laureyn, Katarina Verhaegen, Iwijn De Vlaminck, Liesbet Lagae and Gustaaf Borghs Localized surface plasmon resonance biosensor integrated with microfluidic chip, Biomedical microdevices, 11, 893 (2009).

Jian Ye, Pol Van Dorpe, Willem Van Roy, Kristof Lodewijks, Iwijn De Vlaminck, Guido Maes and Gustaaf Borghs Fabrication and optical properties of gold semishells, Journal of Physical Chemistry C, 113, 3110 (2009).

Pieter Neutens, Pol Van Dorpe, Iwijn De Vlaminck, Liesbet Lagae, Gustaaf Borghs, Electrical detection of confined gap plasmons in metal insulator metal waveguides, Nature Photonics, 3, 283 (2009).

Sotiris masmanidis, Rassul Karabalin, Iwijn De Vlaminck, Gustaaf Borghs, Mark R. Freeman, Michael L. Roukes Multifunctional nanomechanical systems via tunably-coupled piezoelectric actuation, Science, 317, 717 (2007).

Iwijn De Vlaminck, Pol Van Dorpe, Liesbet Lagae, Gustaaf Borghs, Local electrical detection of single nanoparticle plasmon resonance, Nano Letters, 7, 703 (2007).

Iwijn De Vlaminck, Joris Roels, Dirk Taillaert, Dries Van Thourhout, Liesbet Lagae, Roel Baets, Gustaaf Borghs, Detection of nanomechanical motion through evanescent light-wave coupling, Applied Physics Letters, 90, 233116 (2007).

Iwijn De Vlaminck, Kristiaan De Greve, Liesbet Lagae, Gustaaf Borghs, Silicon nanomechanical resonators with double-triangle cross section leading to an enhanced mass sensitivity, Applied Physics Letters, 88, 063112 (2006).